This tweak controls the use of the Run command on the local machine.

[Start] [Run] [Regedit]
Registry Key: HKEY_LOCAL_MACHINE\Software\Microsoft\Windows\CurrentVersion\ Policies\Explorer
Create a DWORD value for each Run function that will be disabled.

Modify/Create the Value Name [DisableLocalMachineRun] according to the Value Data listed below.
Data Type: REG_DWORD [Dword Value] // Value Name: DisableLocalMachineRun

Modify/Create the Value Name [DisableLocalMachineRunOnce] according to the Value Data listed below.
Data Type: REG_DWORD [Dword Value] // Value Name: DisableLocalMachineRunOnce

Modify/Create the Value Name [DisableCurrentUserRun] according to the Value Data listed below.
Data Type: REG_DWORD [Dword Value] // Value Name: DisableCurrentUserRun

Modify/Create the Value Name [DisableCurrentUserRunOnce] according to the Value Data listed below.
Data Type: REG_DWORD [Dword Value] // Value Name: DisableCurrentUserRunOnce

Setting for Value Data: [0 = Disabled / 1 = Enabled]
Exit Registry and Reboot